Color measurement of liquid biopharmaceutical products with the UltraScan VIS spectrophotometer

USP-Color-Standards-HunterLabIn the pharmaceutical industry, the precise determination of the color of transparent liquid products is crucial in development and quality management. Accurate color measurement in transmission according to CIE and ASTM standards is essential to qualify the color of liquid APIs, injectables and other liquid products according to international pharmaceutical guidelines. In particular, the exact assignment of internationally defined color numbers must be guaranteed even for the smallest sample quantities. HunterLab color measurement offers the perfect solution to meet these requirements, providing the pharmaceutical industry with reliable, accurate color values and color numbers – even with minimal sample quantities.

HunterLab-Application-Small+LiquidsThe task

In addition to the exact measurement of the CIE L*a*b* color values, the reliable determination of various color numbers, such as the EP color number EP 2.2.2, the USP color number, the Apha color number or the determination of the Haze value in the analysis of pharmaceutical liquids is also required. When measuring color in transmission, often only very small quantities of the product are available.

Available color numbers:

  • EP (European Pharmacopeia)
  • USP (US Pharmacopeia)
  • CS (Chinese Pharmacopeia)
  • Apha
  • Gardner
  • Lovibond
  • Saybolt
The solution

With the UltraScan VIS spectrophotometer, transparent liquid pharmaceutical products can be precisely measured in transmission. In the EasyMatch QC software, all color numbers commonly used in the pharmaceutical industry can be calculated and displayed immediately in addition to the standard color scales (see box). If you only want to use very small sample quantities, HunterLab offers various holders and cuvettes that can be used to measure quantities from approx. 300 µl. The layer thickness of 1.0 cm is retained for reliable measurement.


The measurement is very simple:

  • Fill the cuvette with liquid
  • Insert the cuvette into the holder
  • Trigger measurement
  • Read measured values in the software

The accessories

The following cuvettes with matching holder:

  • Rectangular cuvettes with layer thicknesses from 2 mm to 50 mm
  • Macro cuvettes (from 2.5 ml)
  • Semi-microcuvettes (from 0.6 ml)
  • Ultra-microcuvettes (from 300 µl)

The blog about color measurement

All about color measurement

The HunterLab Europe company blog keeps you up to date on applications and measurement methods, product presentations and company news. Our spectrophotometry experts regularly give you an overview of the colorful and diverse world of color measurement.
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